SEARCH OUR PRODUCT CATALOG

PTEN-RNLS Fusion FISH Probe

The PTEN-RNLS Fusion FISH Probe is used to confirm a fusion of the PTEN and RNLS genes. The fusion of the PTEN and RNLS genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTEN-RNLS-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTEN-RNLS-20-RERE 20 (40 μL) 200 μL
PTEN-RNLS-20-REOR 20 (40 μL) 200 μL
PTEN-RNLS-20-REGO 20 (40 μL) 200 μL
PTEN-RNLS-20-REGR 20 (40 μL) 200 μL
PTEN-RNLS-20-REAQ 20 (40 μL) 200 μL
PTEN-RNLS-20-ORRE 20 (40 μL) 200 μL
PTEN-RNLS-20-OROR 20 (40 μL) 200 μL
PTEN-RNLS-20-ORGO 20 (40 μL) 200 μL
PTEN-RNLS-20-ORAQ 20 (40 μL) 200 μL
PTEN-RNLS-20-GORE 20 (40 μL) 200 μL
PTEN-RNLS-20-GOOR 20 (40 μL) 200 μL
PTEN-RNLS-20-GOGO 20 (40 μL) 200 μL
PTEN-RNLS-20-GOGR 20 (40 μL) 200 μL
PTEN-RNLS-20-GOAQ 20 (40 μL) 200 μL
PTEN-RNLS-20-GRRE 20 (40 μL) 200 μL
PTEN-RNLS-20-GROR 20 (40 μL) 200 μL
PTEN-RNLS-20-GRGO 20 (40 μL) 200 μL
PTEN-RNLS-20-GRGR 20 (40 μL) 200 μL
PTEN-RNLS-20-GRAQ 20 (40 μL) 200 μL
PTEN-RNLS-20-AQRE 20 (40 μL) 200 μL
PTEN-RNLS-20-AQOR 20 (40 μL) 200 μL
PTEN-RNLS-20-AQGO 20 (40 μL) 200 μL
PTEN-RNLS-20-AQGR 20 (40 μL) 200 μL
PTEN-RNLS-20-AQAQ 20 (40 μL) 200 μL

PTEN Gene Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Gene Name: Phosphatase And Tensin Homolog

Chromosome: CHR10: 89623194 -89728532

Locus: 10q23.31

RNLS Gene Summary

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

Gene Name: Renalase, FAD Dependent Amine Oxidase

Chromosome: CHR10: 90033620 -90343082

Locus: 10q23.31

Gene Diseases

The PTEN RNLS Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.