PTEN-BTRC Fusion FISH Probe
The PTEN-BTRC Fusion FISH Probe is used to confirm a fusion of the PTEN and BTRC genes. The fusion of the PTEN and BTRC genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTEN-BTRC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PTEN-BTRC-20-AQAQ | 20 (40 μL) | 200 μL |
|
PTEN Gene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Name: Phosphatase And Tensin Homolog
Chromosome: CHR10: 89623194 -89728532
Locus: 10q23.31
BTRC Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Gene Name: Beta-transducin Repeat Containing E3 Ubiquitin Protein Ligase
Chromosome: CHR10: 103113824 -103317070
Locus: 10q24.32
Gene Diseases
The PTEN BTRC Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|