PTDSS1-PTK2 Fusion FISH Probe
The PTDSS1-PTK2 Fusion FISH Probe is used to confirm a fusion of the PTDSS1 and PTK2 genes. The fusion of the PTDSS1 and PTK2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTDSS1-PTK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-RERE | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-REOR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-REGO | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-REGR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-REAQ | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-ORRE | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-OROR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-ORGO | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GORE | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GOOR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GOGO | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GOGR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GRRE | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GROR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GRGO | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GRGR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-AQRE | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-AQOR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-AQGO | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-AQGR | 20 (40 μL) | 200 μL |
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| PTDSS1-PTK2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTK2 Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Protein Tyrosine Kinase 2
Chromosome: CHR8: 141668480 -142011412
Locus: 8q24.3
PTDSS1 Gene Summary
The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Gene Name: Phosphatidylserine Synthase 1
Chromosome: CHR8: 97274166 -97346774
Locus: 8q22.1
Gene Diseases
The PTDSS1 PTK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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