PTCH1-IPPK Fusion FISH Probe
The PTCH1-IPPK Fusion FISH Probe is used to confirm a fusion of the PTCH1 and IPPK genes. The fusion of the PTCH1 and IPPK genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTCH1-IPPK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-RERE | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-REOR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-REGO | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-REGR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-REAQ | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-ORRE | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-OROR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-ORGO | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GORE | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GOOR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GOGO | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GOGR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GRRE | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GROR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GRGO | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GRGR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-AQRE | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-AQOR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-AQGO | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-AQGR | 20 (40 μL) | 200 μL |
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| PTCH1-IPPK-20-AQAQ | 20 (40 μL) | 200 μL |
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PTCH1 Gene Summary
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]
Gene Name: Patched 1
Chromosome: CHR9: 98205263 -98279247
Locus: 9q22.32
IPPK Gene Summary
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Gene Name: Inositol-pentakisphosphate 2-kinase
Chromosome: CHR9: 95375465 -95432547
Locus: 9q22.31
Gene Diseases
The PTCH1 IPPK Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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