PTBP1-UBE3C Fusion FISH Probe
The PTBP1-UBE3C Fusion FISH Probe is used to confirm a fusion of the PTBP1 and UBE3C genes. The fusion of the PTBP1 and UBE3C genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTBP1-UBE3C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-RERE | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-REOR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-REGO | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-REGR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-REAQ | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-ORRE | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-OROR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-ORGO | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GORE | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GOOR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GOGO | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GOGR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GRRE | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GROR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GRGO | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GRGR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-AQRE | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-AQOR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-AQGO | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-AQGR | 20 (40 μL) | 200 μL |
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| PTBP1-UBE3C-20-AQAQ | 20 (40 μL) | 200 μL |
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PTBP1 Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Polypyrimidine Tract Binding Protein 1
Chromosome: CHR19: 797391 -812327
Locus: 19p13.3
UBE3C Gene Summary
The Ubiquitin Protein Ligase E3C (UBE3C) gene is located on chr7 :156931654-157062066 at 7q36.3.
Gene Name: Ubiquitin Protein Ligase E3C
Chromosome: CHR7: 156931654 -157062066
Locus: 7q36.3
Gene Diseases
The PTBP1 UBE3C Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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