PTBP1-PALM Fusion FISH Probe
The PTBP1-PALM Fusion FISH Probe is used to confirm a fusion of the PTBP1 and PALM genes. The fusion of the PTBP1 and PALM genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTBP1-PALM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-RERE | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-REOR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-REGO | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-REGR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-REAQ | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-ORRE | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-OROR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-ORGO | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GORE | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GOOR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GOGO | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GOGR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GRRE | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GROR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GRGO | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GRGR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-AQRE | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-AQOR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-AQGO | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-AQGR | 20 (40 μL) | 200 μL |
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| PTBP1-PALM-20-AQAQ | 20 (40 μL) | 200 μL |
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PALM Gene Summary
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Paralemmin
Chromosome: CHR19: 708952 -748330
Locus: 19p13.3
PTBP1 Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Polypyrimidine Tract Binding Protein 1
Chromosome: CHR19: 797391 -812327
Locus: 19p13.3
Gene Diseases
The PTBP1 PALM Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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