PSPC1-ARHGEF2 Fusion FISH Probe
The PSPC1-ARHGEF2 Fusion FISH Probe is used to confirm a fusion of the PSPC1 and ARHGEF2 genes. The fusion of the PSPC1 and ARHGEF2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSPC1-ARHGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| PSPC1-ARHGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARHGEF2 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Gene Name: Rho/Rac Guanine Nucleotide Exchange Factor 2
Chromosome: CHR1: 155916629 -155948336
Locus: 1q22
PSPC1 Gene Summary
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
Gene Name: Paraspeckle Component 1
Chromosome: CHR13: 20248891 -20357159
Locus: 13q12.11
Gene Diseases
The PSPC1 ARHGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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