PSMF1-CHST8 Fusion FISH Probe
The PSMF1-CHST8 Fusion FISH Probe is used to confirm a fusion of the PSMF1 and CHST8 genes. The fusion of the PSMF1 and CHST8 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMF1-CHST8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-RERE | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-REOR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-REGO | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-REGR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-OROR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GORE | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GROR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMF1-CHST8-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMF1 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome Inhibitor Subunit 1
Chromosome: CHR20: 1093905 -1148426
Locus: 20p13
CHST8 Gene Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Carbohydrate Sulfotransferase 8
Chromosome: CHR19: 34112860 -34264414
Locus: 19q13.11
Gene Diseases
The PSMF1 CHST8 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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