PSME1-AP1G2 Fusion FISH Probe
The PSME1-AP1G2 Fusion FISH Probe is used to confirm a fusion of the PSME1 and AP1G2 genes. The fusion of the PSME1 and AP1G2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSME1-AP1G2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-RERE | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-REOR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-REGO | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-REGR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-REAQ | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-ORRE | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-OROR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-ORGO | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GORE | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GOOR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GOGO | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GOGR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GRRE | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GROR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GRGO | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GRGR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-AQRE | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-AQOR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-AQGO | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-AQGR | 20 (40 μL) | 200 μL |
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| PSME1-AP1G2-20-AQAQ | 20 (40 μL) | 200 μL |
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PSME1 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Proteasome Activator Subunit 1
Chromosome: CHR14: 24605377 -24608176
Locus: 14q12
AP1G2 Gene Summary
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Gene Name: Adaptor Related Protein Complex 1 Gamma 2 Subunit
Chromosome: CHR14: 24028776 -24037279
Locus: 14q11.2
Gene Diseases
The PSME1 AP1G2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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