PSMD13-HSD17B12 Fusion FISH Probe
The PSMD13-HSD17B12 Fusion FISH Probe is used to confirm a fusion of the PSMD13 and HSD17B12 genes. The fusion of the PSMD13 and HSD17B12 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMD13-HSD17B12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-RERE | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-REOR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-REGO | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-REGR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-OROR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GORE | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GROR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMD13-HSD17B12-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD13 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome 26S Subunit, Non-ATPase 13
Chromosome: CHR11: 236807 -252984
Locus: 11p15.5
HSD17B12 Gene Summary
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Gene Name: Hydroxysteroid 17-beta Dehydrogenase 12
Chromosome: CHR11: 43702142 -43878169
Locus: 11p11.2
Gene Diseases
The PSMD13 HSD17B12 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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