PSMD12-KIAA2022 Fusion FISH Probe
The PSMD12-KIAA2022 Fusion FISH Probe is used to confirm a fusion of the PSMD12 and KIAA2022 genes. The fusion of the PSMD12 and KIAA2022 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMD12-KIAA2022-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-RERE | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-REOR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-REGO | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-REGR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-OROR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GORE | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GROR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMD12-KIAA2022-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD12 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Proteasome 26S Subunit, Non-ATPase 12
Chromosome: CHR17: 65336618 -65362721
Locus: 17q24.2
Gene Diseases
The PSMD12 KIAA2022 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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