PSMD1-NHEJ1 Fusion FISH Probe
The PSMD1-NHEJ1 Fusion FISH Probe is used to confirm a fusion of the PSMD1 and NHEJ1 genes. The fusion of the PSMD1 and NHEJ1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMD1-NHEJ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-RERE | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-REOR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-REGO | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-REGR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-OROR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GORE | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GROR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMD1-NHEJ1-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD1 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Name: Proteasome 26S Subunit, Non-ATPase 1
Chromosome: CHR2: 231921577 -232037540
Locus: 2q37.1
NHEJ1 Gene Summary
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
Gene Name: Non-homologous End Joining Factor 1
Chromosome: CHR2: 219940045 -220025587
Locus: 2q35
Gene Diseases
The PSMD1 NHEJ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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