PSMD1-ATP2C1 Fusion FISH Probe
The PSMD1-ATP2C1 Fusion FISH Probe is used to confirm a fusion of the PSMD1 and ATP2C1 genes. The fusion of the PSMD1 and ATP2C1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMD1-ATP2C1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-RERE | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-REOR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-REGO | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-REGR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-OROR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GORE | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GROR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMD1-ATP2C1-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD1 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Name: Proteasome 26S Subunit, Non-ATPase 1
Chromosome: CHR2: 231921577 -232037540
Locus: 2q37.1
ATP2C1 Gene Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: ATPase Secretory Pathway Ca2+ Transporting 1
Chromosome: CHR3: 130569368 -130735555
Locus: 3q22.1
Gene Diseases
The PSMD1 ATP2C1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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