PSMC6-GPR137C Fusion FISH Probe
The PSMC6-GPR137C Fusion FISH Probe is used to confirm a fusion of the PSMC6 and GPR137C genes. The fusion of the PSMC6 and GPR137C genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMC6-GPR137C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-RERE | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-REOR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-REGO | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-REGR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-OROR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GORE | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GROR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMC6-GPR137C-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMC6 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome 26S Subunit, ATPase 6
Chromosome: CHR14: 53173895 -53194716
Locus: 14q22.1
GPR137C Gene Summary
The G Protein-coupled Receptor 137C (GPR137C) gene is located on chr14 :53019865-53104431 at 14q22.1.
Gene Name: G Protein-coupled Receptor 137C
Chromosome: CHR14: 53019865 -53104431
Locus: 14q22.1
Gene Diseases
The PSMC6 GPR137C Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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