PSMA1-CCT5 Fusion FISH Probe
The PSMA1-CCT5 Fusion FISH Probe is used to confirm a fusion of the PSMA1 and CCT5 genes. The fusion of the PSMA1 and CCT5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSMA1-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| PSMA1-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMA1 Gene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Gene Name: Proteasome Subunit Alpha 1
Chromosome: CHR11: 14526421 -14665180
Locus: 11p15.2
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The PSMA1 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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