PSEN1-ACSM1 Fusion FISH Probe
The PSEN1-ACSM1 Fusion FISH Probe is used to confirm a fusion of the PSEN1 and ACSM1 genes. The fusion of the PSEN1 and ACSM1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSEN1-ACSM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-RERE | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-REOR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-REGO | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-REGR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-REAQ | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-ORRE | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-OROR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-ORGO | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GORE | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GOOR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GOGO | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GOGR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GRRE | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GROR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GRGO | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GRGR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-AQRE | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-AQOR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-AQGO | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-AQGR | 20 (40 μL) | 200 μL |
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| PSEN1-ACSM1-20-AQAQ | 20 (40 μL) | 200 μL |
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PSEN1 Gene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Gene Name: Presenilin 1
Chromosome: CHR14: 73603142 -73690399
Locus: 14q24.2
ACSM1 Gene Summary
The Acyl-CoA Synthetase Medium Chain Family Member 1 (ACSM1) gene is located on chr16 :20634558-20702578 at 16p12.3.
Gene Name: Acyl-CoA Synthetase Medium Chain Family Member 1
Chromosome: CHR16: 20634558 -20702578
Locus: 16p12.3
Gene Diseases
The PSEN1 ACSM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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