PSAP-TYK2 Fusion FISH Probe
The PSAP-TYK2 Fusion FISH Probe is used to confirm a fusion of the PSAP and TYK2 genes. The fusion of the PSAP and TYK2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The PSAP TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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