PSAP-TSPAN8 Fusion FISH Probe
The PSAP-TSPAN8 Fusion FISH Probe is used to confirm a fusion of the PSAP and TSPAN8 genes. The fusion of the PSAP and TSPAN8 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PSAP-TSPAN8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PSAP-TSPAN8-20-AQAQ | 20 (40 μL) | 200 μL |
|
PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
TSPAN8 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tetraspanin 8
Chromosome: CHR12: 71518876 -71551779
Locus: 12q21.1
Gene Diseases
The PSAP TSPAN8 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|