PSAP-FOXP1 Fusion FISH Probe
The PSAP-FOXP1 Fusion FISH Probe is used to confirm a fusion of the PSAP and FOXP1 genes. The fusion of the PSAP and FOXP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The PSAP FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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