PSAP-DDX27 Fusion FISH Probe
The PSAP-DDX27 Fusion FISH Probe is used to confirm a fusion of the PSAP and DDX27 genes. The fusion of the PSAP and DDX27 genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The PSAP DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Uveal Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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