PSAP-C7 Fusion FISH Probe
The PSAP-C7 Fusion FISH Probe is used to confirm a fusion of the PSAP and C7 genes. The fusion of the PSAP and C7 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
Gene Diseases
The PSAP C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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