PSAP-C3 Fusion FISH Probe
The PSAP-C3 Fusion FISH Probe is used to confirm a fusion of the PSAP and C3 genes. The fusion of the PSAP and C3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSAP-C3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-RERE | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-REOR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-REGO | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-REGR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-REAQ | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-ORRE | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-OROR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-ORGO | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GORE | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GOOR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GOGO | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GOGR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GRRE | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GROR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GRGO | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GRGR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-AQRE | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-AQOR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-AQGO | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-AQGR | 20 (40 μL) | 200 μL |
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| PSAP-C3-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
Gene Diseases
The PSAP C3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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