PRUNE2-GNA14 Fusion FISH Probe
The PRUNE2-GNA14 Fusion FISH Probe is used to confirm a fusion of the PRUNE2 and GNA14 genes. The fusion of the PRUNE2 and GNA14 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRUNE2-GNA14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-RERE | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-REOR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-REGO | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-REGR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-REAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-ORRE | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-OROR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-ORGO | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GORE | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GOOR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GOGO | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GOGR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GRRE | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GROR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GRGO | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GRGR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-AQRE | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-AQOR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-AQGO | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-AQGR | 20 (40 μL) | 200 μL |
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| PRUNE2-GNA14-20-AQAQ | 20 (40 μL) | 200 μL |
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GNA14 Gene Summary
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Gene Name: G Protein Subunit Alpha 14
Chromosome: CHR9: 80037994 -80263232
Locus: 9q21.2
PRUNE2 Gene Summary
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Gene Name: Prune Homolog 2
Chromosome: CHR9: 79226291 -79521003
Locus: 9q21.2
Gene Diseases
The PRUNE2 GNA14 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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