PRR5-ARHGAP8-XRCC6 Fusion FISH Probe
The PRR5-ARHGAP8-XRCC6 Fusion FISH Probe is used to confirm a fusion of the PRR5-ARHGAP8 and XRCC6 genes. The fusion of the PRR5-ARHGAP8 and XRCC6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRR5-ARHGAP8-XRCC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-RERE | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-REOR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-REGO | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-REGR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-REAQ | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-ORRE | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-OROR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-ORGO | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GORE | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GOOR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GOGO | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GOGR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GRRE | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GROR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GRGO | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GRGR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-AQRE | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-AQOR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-AQGO | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-AQGR | 20 (40 μL) | 200 μL |
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| PRR5-ARHGAP8-XRCC6-20-AQAQ | 20 (40 μL) | 200 μL |
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XRCC6 Gene Summary
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Gene Name: X-ray Repair Cross Complementing 6
Chromosome: CHR22: 42017294 -42060052
Locus: 22q13.2
PRR5-ARHGAP8 Gene Summary
The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010]
Gene Name: PRR5-ARHGAP8 Readthrough
Chromosome: CHR22: 45098381 -45258664
Locus: 22q13.31
Gene Diseases
The PRR5-ARHGAP8 XRCC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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