PRR12-PRRG2 Fusion FISH Probe
The PRR12-PRRG2 Fusion FISH Probe is used to confirm a fusion of the PRR12 and PRRG2 genes. The fusion of the PRR12 and PRRG2 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRR12-PRRG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-RERE | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-REOR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-REGO | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-REGR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-REAQ | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-ORRE | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-OROR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-ORGO | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GORE | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GOOR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GOGO | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GOGR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GRRE | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GROR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GRGO | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GRGR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-AQRE | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-AQOR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-AQGO | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-AQGR | 20 (40 μL) | 200 μL |
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| PRR12-PRRG2-20-AQAQ | 20 (40 μL) | 200 μL |
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PRRG2 Gene Summary
The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Proline Rich And Gla Domain 2
Chromosome: CHR19: 50084586 -50094265
Locus: 19q13.33
PRR12 Gene Summary
This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016]
Gene Name: Proline Rich 12
Chromosome: CHR19: 50094911 -50129696
Locus: 19q13.33
Gene Diseases
The PRR12 PRRG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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