PRPF19-DDB1 Fusion FISH Probe
The PRPF19-DDB1 Fusion FISH Probe is used to confirm a fusion of the PRPF19 and DDB1 genes. The fusion of the PRPF19 and DDB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRPF19-DDB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-RERE | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-REOR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-REGO | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-REGR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-REAQ | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-ORRE | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-OROR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-ORGO | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GORE | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GOOR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GOGO | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GOGR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GRRE | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GROR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GRGO | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GRGR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-AQRE | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-AQOR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-AQGO | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-AQGR | 20 (40 μL) | 200 μL |
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| PRPF19-DDB1-20-AQAQ | 20 (40 μL) | 200 μL |
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DDB1 Gene Summary
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Gene Name: Damage Specific DNA Binding Protein 1
Chromosome: CHR11: 61066918 -61100666
Locus: 11q12.2
PRPF19 Gene Summary
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]
Gene Name: Pre-mRNA Processing Factor 19
Chromosome: CHR11: 60658019 -60674061
Locus: 11q12.2
Gene Diseases
The PRPF19 DDB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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