PRKX-CLCN4 Fusion FISH Probe
The PRKX-CLCN4 Fusion FISH Probe is used to confirm a fusion of the PRKX and CLCN4 genes. The fusion of the PRKX and CLCN4 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKX-CLCN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-RERE | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-REOR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-REGO | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-REGR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-OROR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GORE | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GROR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKX-CLCN4-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN4 Gene Summary
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Gene Name: Chloride Voltage-gated Channel 4
Chromosome: CHRX: 10124984 -10205699
Locus: Xp22.2
PRKX Gene Summary
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
Gene Name: Protein Kinase, X-linked
Chromosome: CHRX: 3522383 -3631675
Locus: Xp22.33
Gene Diseases
The PRKX CLCN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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