PRKDC-CA3 Fusion FISH Probe
The PRKDC-CA3 Fusion FISH Probe is used to confirm a fusion of the PRKDC and CA3 genes. The fusion of the PRKDC and CA3 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKDC-CA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-RERE | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-REOR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-REGO | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-REGR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-OROR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GORE | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GROR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKDC-CA3-20-AQAQ | 20 (40 μL) | 200 μL |
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CA3 Gene Summary
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
Gene Name: Carbonic Anhydrase 3
Chromosome: CHR8: 86351055 -86361267
Locus: 8q21.2
PRKDC Gene Summary
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
Gene Name: Protein Kinase, DNA-activated, Catalytic Polypeptide
Chromosome: CHR8: 48685668 -48872743
Locus: 8q11.21
Gene Diseases
The PRKDC CA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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