PRKCZ-GABRD Fusion FISH Probe
The PRKCZ-GABRD Fusion FISH Probe is used to confirm a fusion of the PRKCZ and GABRD genes. The fusion of the PRKCZ and GABRD genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKCZ-GABRD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PRKCZ-GABRD-20-AQAQ | 20 (40 μL) | 200 μL |
|
GABRD Gene Summary
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Gamma-aminobutyric Acid Type A Receptor Delta Subunit
Chromosome: CHR1: 1950767 -1962192
Locus: 1p36.33
PRKCZ Gene Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Zeta
Chromosome: CHR1: 1981908 -2116834
Locus: 1p36.33
Gene Diseases
The PRKCZ GABRD Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|