PRKCI-TNIK Fusion FISH Probe
The PRKCI-TNIK Fusion FISH Probe is used to confirm a fusion of the PRKCI and TNIK genes. The fusion of the PRKCI and TNIK genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKCI-TNIK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-RERE | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-REOR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-REGO | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-REGR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-OROR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GORE | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GROR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKCI-TNIK-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCI Gene Summary
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Iota
Chromosome: CHR3: 169940219 -170023770
Locus: 3q26.2
TNIK Gene Summary
Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: TRAF2 And NCK Interacting Kinase
Chromosome: CHR3: 170780291 -171178197
Locus: 3q26.2-q26.31
Gene Diseases
The PRKCI TNIK Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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