PRKCA-RPS6KB1 Fusion FISH Probe
The PRKCA-RPS6KB1 Fusion FISH Probe is used to confirm a fusion of the PRKCA and RPS6KB1 genes. The fusion of the PRKCA and RPS6KB1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKCA-RPS6KB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-RERE | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-REOR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-REGO | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-REGR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-OROR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GORE | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GROR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKCA-RPS6KB1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCA Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Alpha
Chromosome: CHR17: 64298925 -64806862
Locus: 17q24.2
RPS6KB1 Gene Summary
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Gene Name: Ribosomal Protein S6 Kinase B1
Chromosome: CHR17: 57970442 -58027786
Locus: 17q23.1
Gene Diseases
The PRKCA RPS6KB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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