PRKAR2B-HMCN1 Fusion FISH Probe
The PRKAR2B-HMCN1 Fusion FISH Probe is used to confirm a fusion of the PRKAR2B and HMCN1 genes. The fusion of the PRKAR2B and HMCN1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKAR2B-HMCN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PRKAR2B-HMCN1-20-AQAQ | 20 (40 μL) | 200 μL |
|
PRKAR2B Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Beta
Chromosome: CHR7: 106685177 -106802256
Locus: 7q22.3
HMCN1 Gene Summary
This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008]
Gene Name: Hemicentin 1
Chromosome: CHR1: 185703682 -186160085
Locus: 1q25.3-q31.1
Gene Diseases
The PRKAR2B HMCN1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|