PRKAR2A-CACNA2D3 Fusion FISH Probe
The PRKAR2A-CACNA2D3 Fusion FISH Probe is used to confirm a fusion of the PRKAR2A and CACNA2D3 genes. The fusion of the PRKAR2A and CACNA2D3 genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAR2A-CACNA2D3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-RERE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-REOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-REGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-OROR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA2D3-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR2A Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Alpha
Chromosome: CHR3: 48788092 -48885270
Locus: 3p21.31
CACNA2D3 Gene Summary
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 3
Chromosome: CHR3: 54156692 -55108584
Locus: 3p21.1-p14.3
Gene Diseases
The PRKAR2A CACNA2D3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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