PRKAR2A-CACNA1D Fusion FISH Probe
The PRKAR2A-CACNA1D Fusion FISH Probe is used to confirm a fusion of the PRKAR2A and CACNA1D genes. The fusion of the PRKAR2A and CACNA1D genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAR2A-CACNA1D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-RERE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-REOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-REGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-OROR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKAR2A-CACNA1D-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1D Gene Summary
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 D
Chromosome: CHR3: 53529030 -53846492
Locus: 3p21.1
PRKAR2A Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Alpha
Chromosome: CHR3: 48788092 -48885270
Locus: 3p21.31
Gene Diseases
The PRKAR2A CACNA1D Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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