PRKAB2-FBP2 Fusion FISH Probe
The PRKAB2-FBP2 Fusion FISH Probe is used to confirm a fusion of the PRKAB2 and FBP2 genes. The fusion of the PRKAB2 and FBP2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAB2-FBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-RERE | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-REOR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-REGR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-OROR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| PRKAB2-FBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAB2 Gene Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Protein Kinase AMP-activated Non-catalytic Subunit Beta 2
Chromosome: CHR1: 146626684 -146644129
Locus: 1q21.1
FBP2 Gene Summary
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]
Gene Name: Fructose-bisphosphatase 2
Chromosome: CHR9: 97321002 -97356075
Locus: 9q22.32
Gene Diseases
The PRKAB2 FBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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