PRICKLE2-ADAMTS9 Fusion FISH Probe
The PRICKLE2-ADAMTS9 Fusion FISH Probe is used to confirm a fusion of the PRICKLE2 and ADAMTS9 genes. The fusion of the PRICKLE2 and ADAMTS9 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRICKLE2-ADAMTS9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-RERE | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-REOR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-REGO | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-REGR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-REAQ | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-ORRE | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-OROR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-ORGO | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GORE | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GOOR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GOGO | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GOGR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GRRE | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GROR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GRGO | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GRGR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-AQRE | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-AQOR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-AQGO | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-AQGR | 20 (40 μL) | 200 μL |
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| PRICKLE2-ADAMTS9-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAMTS9 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9
Chromosome: CHR3: 64501330 -64673365
Locus: 3p14.1
PRICKLE2 Gene Summary
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
Gene Name: Prickle Planar Cell Polarity Protein 2
Chromosome: CHR3: 64079525 -64211131
Locus: 3p14.1
Gene Diseases
The PRICKLE2 ADAMTS9 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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