PRCP-DLG2 Fusion FISH Probe
The PRCP-DLG2 Fusion FISH Probe is used to confirm a fusion of the PRCP and DLG2 genes. The fusion of the PRCP and DLG2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRCP-DLG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-RERE | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-REOR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-REGO | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-REGR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-REAQ | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-ORRE | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-OROR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-ORGO | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GORE | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GOOR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GOGO | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GOGR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GRRE | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GROR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GRGO | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GRGR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-AQRE | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-AQOR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-AQGO | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-AQGR | 20 (40 μL) | 200 μL |
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| PRCP-DLG2-20-AQAQ | 20 (40 μL) | 200 μL |
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DLG2 Gene Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Gene Name: Discs Large MAGUK Scaffold Protein 2
Chromosome: CHR11: 83166055 -85338314
Locus: 11q14.1
PRCP Gene Summary
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Prolylcarboxypeptidase
Chromosome: CHR11: 82535408 -82611557
Locus: 11q14.1
Gene Diseases
The PRCP DLG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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