PRC1-VPS33B Fusion FISH Probe
The PRC1-VPS33B Fusion FISH Probe is used to confirm a fusion of the PRC1 and VPS33B genes. The fusion of the PRC1 and VPS33B genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRC1-VPS33B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-RERE | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-REOR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-REGO | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-REGR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-REAQ | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-ORRE | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-OROR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-ORGO | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GORE | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GOOR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GOGO | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GOGR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GRRE | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GROR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GRGO | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GRGR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-AQRE | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-AQOR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-AQGO | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-AQGR | 20 (40 μL) | 200 μL |
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| PRC1-VPS33B-20-AQAQ | 20 (40 μL) | 200 μL |
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PRC1 Gene Summary
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Name: Protein Regulator Of Cytokinesis 1
Chromosome: CHR15: 91509267 -91537804
Locus: 15q26.1
VPS33B Gene Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: VPS33B, Late Endosome And Lysosome Associated
Chromosome: CHR15: 91541773 -91565833
Locus: 15q26.1
Gene Diseases
The PRC1 VPS33B Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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