PPT2-TNF Fusion FISH Probe
The PPT2-TNF Fusion FISH Probe is used to confirm a fusion of the PPT2 and TNF genes. The fusion of the PPT2 and TNF genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPT2-TNF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-RERE | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-REOR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-REGO | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-REGR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-REAQ | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-ORRE | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-OROR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-ORGO | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GORE | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GOOR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GOGO | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GOGR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GRRE | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GROR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GRGO | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GRGR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-AQRE | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-AQOR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-AQGO | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-AQGR | 20 (40 μL) | 200 μL |
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| PPT2-TNF-20-AQAQ | 20 (40 μL) | 200 μL |
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TNF Gene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Gene Name: Tumor Necrosis Factor
Chromosome: CHR6_qbl_hap6: 2836987 -2839752
Locus: 6p21.33
PPT2 Gene Summary
This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
Gene Name: Palmitoyl-protein Thioesterase 2
Chromosome: CHR6_cox_hap2: 3591896 -3602139
Locus: 6p21.32
Gene Diseases
The PPT2 TNF Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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