PPP5C-AP2S1 Fusion FISH Probe
The PPP5C-AP2S1 Fusion FISH Probe is used to confirm a fusion of the PPP5C and AP2S1 genes. The fusion of the PPP5C and AP2S1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP5C-AP2S1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-RERE | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-REOR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-REGO | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-REGR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-OROR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GORE | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GROR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP5C-AP2S1-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2S1 Gene Summary
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Adaptor Related Protein Complex 2 Sigma 1 Subunit
Chromosome: CHR19: 47341422 -47354203
Locus: 19q13.32
PPP5C Gene Summary
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Gene Name: Protein Phosphatase 5 Catalytic Subunit
Chromosome: CHR19: 46850250 -46894232
Locus: 19q13.32
Gene Diseases
The PPP5C AP2S1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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