PPP4R4-MYH6 Fusion FISH Probe
The PPP4R4-MYH6 Fusion FISH Probe is used to confirm a fusion of the PPP4R4 and MYH6 genes. The fusion of the PPP4R4 and MYH6 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP4R4-MYH6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-RERE | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-REOR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-REGO | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-REGR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-OROR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GORE | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GROR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP4R4-MYH6-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH6 Gene Summary
Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]
Gene Name: Myosin Heavy Chain 6
Chromosome: CHR14: 23851198 -23877486
Locus: 14q11.2
PPP4R4 Gene Summary
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 4
Chromosome: CHR14: 94640648 -94746072
Locus: 14q32.12-q32.13
Gene Diseases
The PPP4R4 MYH6 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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