PPP4R1-PAWR Fusion FISH Probe
The PPP4R1-PAWR Fusion FISH Probe is used to confirm a fusion of the PPP4R1 and PAWR genes. The fusion of the PPP4R1 and PAWR genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP4R1-PAWR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-RERE | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-REOR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-REGO | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-REGR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-OROR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GORE | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GROR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP4R1-PAWR-20-AQAQ | 20 (40 μL) | 200 μL |
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PAWR Gene Summary
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Gene Name: Pro-apoptotic WT1 Regulator
Chromosome: CHR12: 79985744 -80084790
Locus: 12q21.2
PPP4R1 Gene Summary
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 1
Chromosome: CHR18: 9546791 -9614600
Locus: 18p11.22
Gene Diseases
The PPP4R1 PAWR Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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