PPP4R1-CCNB3 Fusion FISH Probe
The PPP4R1-CCNB3 Fusion FISH Probe is used to confirm a fusion of the PPP4R1 and CCNB3 genes. The fusion of the PPP4R1 and CCNB3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPP4R1-CCNB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PPP4R1-CCNB3-20-AQAQ | 20 (40 μL) | 200 μL |
|
PPP4R1 Gene Summary
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 1
Chromosome: CHR18: 9546791 -9614600
Locus: 18p11.22
CCNB3 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Cyclin B3
Chromosome: CHRX: 50027539 -50094911
Locus: Xp11.22
Gene Diseases
The PPP4R1 CCNB3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|