PPP3CA-COL25A1 Fusion FISH Probe
The PPP3CA-COL25A1 Fusion FISH Probe is used to confirm a fusion of the PPP3CA and COL25A1 genes. The fusion of the PPP3CA and COL25A1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP3CA-COL25A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-RERE | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-REOR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-REGO | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-REGR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-OROR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GORE | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GROR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP3CA-COL25A1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP3CA Gene Summary
The Protein Phosphatase 3 Catalytic Subunit Alpha (PPP3CA) gene is located on chr4 :101944586-102268628 at 4q24.
Gene Name: Protein Phosphatase 3 Catalytic Subunit Alpha
Chromosome: CHR4: 101944586 -102268628
Locus: 4q24
COL25A1 Gene Summary
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Collagen Type XXV Alpha 1 Chain
Chromosome: CHR4: 109734971 -110223799
Locus: 4q25
Gene Diseases
The PPP3CA COL25A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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