PPP2R3C-NFKBIA Fusion FISH Probe
The PPP2R3C-NFKBIA Fusion FISH Probe is used to confirm a fusion of the PPP2R3C and NFKBIA genes. The fusion of the PPP2R3C and NFKBIA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP2R3C-NFKBIA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-RERE | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-REOR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-REGO | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-REGR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-OROR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GORE | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GROR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP2R3C-NFKBIA-20-AQAQ | 20 (40 μL) | 200 μL |
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NFKBIA Gene Summary
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Gene Name: NFKB Inhibitor Alpha
Chromosome: CHR14: 35870715 -35873960
Locus: 14q13.2
PPP2R3C Gene Summary
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B''gamma
Chromosome: CHR14: 35554677 -35591519
Locus: 14q13.2
Gene Diseases
The PPP2R3C NFKBIA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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