PPP1R16A-CLDN4 Fusion FISH Probe
The PPP1R16A-CLDN4 Fusion FISH Probe is used to confirm a fusion of the PPP1R16A and CLDN4 genes. The fusion of the PPP1R16A and CLDN4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R16A-CLDN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R16A-CLDN4-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN4 Gene Summary
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Gene Name: Claudin 4
Chromosome: CHR7: 73245192 -73247015
Locus: 7q11.23
PPP1R16A Gene Summary
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 16A
Chromosome: CHR8: 145722108 -145727504
Locus: 8q24.3
Gene Diseases
The PPP1R16A CLDN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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