PPP1R13B-ZP3 Fusion FISH Probe
The PPP1R13B-ZP3 Fusion FISH Probe is used to confirm a fusion of the PPP1R13B and ZP3 genes. The fusion of the PPP1R13B and ZP3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R13B-ZP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ZP3-20-AQAQ | 20 (40 μL) | 200 μL |
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ZP3 Gene Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Gene Name: Zona Pellucida Glycoprotein 3
Chromosome: CHR7: 76026840 -76071388
Locus: 7q11.23
PPP1R13B Gene Summary
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 13B
Chromosome: CHR14: 104200087 -104313927
Locus: 14q32.33
Gene Diseases
The PPP1R13B ZP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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