PPP1R13B-L2HGDH Fusion FISH Probe
The PPP1R13B-L2HGDH Fusion FISH Probe is used to confirm a fusion of the PPP1R13B and L2HGDH genes. The fusion of the PPP1R13B and L2HGDH genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R13B-L2HGDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-L2HGDH-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1R13B Gene Summary
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 13B
Chromosome: CHR14: 104200087 -104313927
Locus: 14q32.33
L2HGDH Gene Summary
This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008]
Gene Name: L-2-hydroxyglutarate Dehydrogenase
Chromosome: CHR14: 50709151 -50778947
Locus: 14q21.3
Gene Diseases
The PPP1R13B L2HGDH Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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