PPP1R13B-ADAM18 Fusion FISH Probe
The PPP1R13B-ADAM18 Fusion FISH Probe is used to confirm a fusion of the PPP1R13B and ADAM18 genes. The fusion of the PPP1R13B and ADAM18 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R13B-ADAM18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R13B-ADAM18-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM18 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: ADAM Metallopeptidase Domain 18
Chromosome: CHR8: 39442086 -39587583
Locus: 8p11.22
PPP1R13B Gene Summary
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 13B
Chromosome: CHR14: 104200087 -104313927
Locus: 14q32.33
Gene Diseases
The PPP1R13B ADAM18 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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