PPP1R12C-RPL28 Fusion FISH Probe
The PPP1R12C-RPL28 Fusion FISH Probe is used to confirm a fusion of the PPP1R12C and RPL28 genes. The fusion of the PPP1R12C and RPL28 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R12C-RPL28-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-RPL28-20-AQAQ | 20 (40 μL) | 200 μL |
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RPL28 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Gene Name: Ribosomal Protein L28
Chromosome: CHR19: 55897299 -55903451
Locus: 19q13.42
PPP1R12C Gene Summary
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12C
Chromosome: CHR19: 55602280 -55628927
Locus: 19q13.42
Gene Diseases
The PPP1R12C RPL28 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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